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Article

Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 May 1997

Shindler K S, Latham C B, Roth K A

Abstract excerpt

The intracellular balance between pro- and antiapoptotic members of the Bcl-2 gene family is thought to regulate cell death. Targeted disruption of bcl-x, a death repressing member, causes massive cell death of immature neurons in the developing mouse CNS, whereas targeted disruption of bax, a proapoptotic member, blocks the death of specific populations of sympathetic and motor neurons. In the present study,...

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Identifiers

PMID: 9096145
PMCID: PMC6573662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice.PMID 9096145Read ↗

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