Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increase in bax expression and apoptosis are associated in Huntington's disease progression.

Neuroscience letters - 13 Jun 2008

Teles A V F F, Rosenstock T R, Okuno C S, Lopes G S, Bertoncini C R A, Smaili S S

Abstract excerpt

Huntington's disease (HD) is a hereditary dominant neurodegenerative disorder and the progression of the disease may be associated with apoptosis and altered expression of apoptotic proteins. The aim of this study was to investigate gene expression of bax and bcl-2 in tissues from R6/1 transgenic (TGN) mice of different ages (3, 6 and 9 months). The mRNA expression was investigated and related to apoptotic cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Huntington Disease
Share to bcl-2-Associated X Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cerebral Cortex

Share to In Situ Nick-End Labeling

Share to Mice, Inbred CBA

Share to Nerve Degeneration

Share to Proto-Oncogene Proteins c-bcl-2

Share to Up-Regulation

Source

Identifiers

PMID: 18468793
DOI: 10.1016/j.neulet.2008.03.062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increase in bax expression and apoptosis are associated in Huntington's disease progression.PMID 18468793Read ↗

BH3-only proteins Bid and Bim(EL) are differentially involved in neuronal dysfunction in mouse models of Huntington's disease.Semantic proximity Read ↗

Dissociation of Progressive Dopaminergic Neuronal Death and Behavioral Impairments by Bax Deletion in a Mouse Model of Parkinson's DiseasesSemantic proximity Read ↗

Expression pattern of apoptosis-related markers in Huntington’s diseaseSemantic proximity Read ↗

Inhibition of Bax protects neuronal cells from oligomeric Aβ neurotoxicitySemantic proximity Read ↗

PARP-1 Inhibition Is Neuroprotective in the R6/2 Mouse Model of Huntington’s DiseaseSemantic proximity Read ↗

The alpha-5 helix of Bax is sensitive to ubiquitin-dependent degradation.Semantic proximity Read ↗

BAX contributes to Doppel-induced apoptosis of prion-protein-deficient Purkinje cells.Semantic proximity Read ↗

Motor neuron degeneration is attenuated in bax-deficient neurons in vitro.Semantic proximity Read ↗

Apoptosis in experimental rabies in bax-deficient mice.Semantic proximity Read ↗

Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice.Semantic proximity Read ↗

Bax deletion does not protect neurons from BSE-induced death.Semantic proximity Read ↗

Detection of Pro-apoptotic BaxΔ2 Proteins in the Human CerebellumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.