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Article

MAPK-pathway activity, Lrrk2 G2019S, and Parkinson's disease.

Journal of neuroscience research - 1 May 2007

White Linda R, Toft Mathias, Kvam Sylvia N, Farrer Matthew J, Aasly Jan O

Abstract excerpt

The 6055G>A mutation in the leucine-rich repeat kinase 2 (LRRK2) gene results in a G2019S substitution in the mixed-lineage kinase domain of Lrrk2, causing autosomal dominant Parkinson's disease (PD). We hypothesized the mutation alters cellular mitogen-activated protein kinase (MAPK) signalling cascades, and might be detectable in tissues other than in the brain. We therefore compared total levels and activation...

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Source

Identifiers

PMID: 17385669
DOI: 10.1002/jnr.21240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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