MAPK-pathway activity, Lrrk2 G2019S, and Parkinson's disease.

doi:10.1002/jnr.21240

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Article

MAPK-pathway activity, Lrrk2 G2019S, and Parkinson's disease.

Journal of neuroscience research - 1 May 2007

White Linda R, Toft Mathias, Kvam Sylvia N, Farrer Matthew J, Aasly Jan O

Abstract excerpt

The 6055G>A mutation in the leucine-rich repeat kinase 2 (LRRK2) gene results in a G2019S substitution in the mixed-lineage kinase domain of Lrrk2, causing autosomal dominant Parkinson's disease (PD). We hypothesized the mutation alters cellular mitogen-activated protein kinase (MAPK) signalling cascades, and might be detectable in tissues other than in the brain. We therefore compared total levels and activation...

Topics

Aged
Aged, 80 and over
DNA Mutational Analysis
Female
Genetic Predisposition to Disease
Glycine
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Leukocytes
Male
Mitogen-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Norway

Parkinson Disease

Phosphorylation

Protein Serine-Threonine Kinases

Serine

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 17385669
DOI: 10.1002/jnr.21240

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17385669-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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