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Article

DNA sequence requirements for generating paused polymerase at the start of hsp70.

Genes & development - 1 Feb 1992

Lee H, Kraus K W, Wolfner M F, Lis J T

Abstract excerpt

RNA polymerase II is transcriptionally engaged but paused approximately 25 nucleotides from the start site of the hsp70 gene of Drosophila melanogaster in uninduced (non-heat-shocked) flies. Here, we identify regions of the hsp70 promoter that are required for formation of this paused polymerase. Various hsp70 promoter sequences are substituted for promoter sequences of a yolk protein gene, yp1, which, in males,...

Topics

Animals
Animals, Genetically Modified
Base Sequence
Blotting, Northern
Drosophila melanogaster
Gene Expression Regulation
Heat-Shock Proteins
Male
Molecular Sequence Data
Mutation
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Polymerase II

Transcription, Genetic

Source

Identifiers

PMID: 1737619
DOI: 10.1101/gad.6.2.284

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1737619-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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