Heat shock factor gains access to the yeast HSC82 promoter independently of other sequence-specific factors and antagonizes nucleosomal repression of basal and induced transcription.

Abstract excerpt

Transcription in eukaryotic cells occurs in the context of chromatin. Binding of sequence-specific regulatory factors must contend with the presence of nucleosomes for establishment of a committed preinitiation complex. Here we demonstrate that the high-affinity binding site for heat shock transc...

Topics

• Base Sequence
• Fungal Proteins
• Gene Expression Regulation, Fungal
• HSP90 Heat-Shock Proteins
• Heat-Shock Proteins
• Molecular Sequence Data
• Mutation
• Promoter Regions, Genetic
• Saccharomyces cerevisiae
• Saccharomyces cerevisiae Proteins
• TATA Box
• Transcription, Genetic