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Article

Reactivation of Snail Genes in Renal Fibrosis and Carcinomas: A Process of Reversed Embryogenesis?

15 Mar 2007

Abstract excerpt

While the activity of Snail genes is required during embryonic development for the formation of different tissues and organs, they must be repressed in the adult in order to maintain epithelial integrity and homeostasis. Indeed, pathological activation of Snail in epithelial tumors induces malignancy and the recurrence of tumors. Here we show that in dedifferentiated areas of human renal carcinomas, Snail...

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Share to Epigenetics and DNA Methylation
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PMID: 17374993
DOI: 10.4161/cc.6.6.4022

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