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Article

SNAIL is a key regulator of alveolar rhabdomyosarcoma tumor growth and differentiation through repression of MYF5 and MYOD function.

Cell death & disease - 29 May 2018

Skrzypek Klaudia, Kusienicka Anna, Trzyna Elzbieta, Szewczyk Barbara, Ulman Aleksandra, Konieczny Pawel, Adamus Tomasz, Badyra Bogna, Kortylewski Marcin, Majka Marcin

Abstract excerpt

Rhabdomyosarcoma (RMS) is a mesenchymal tumor of soft tissue in children that originates from a myogenic differentiation defect. Expression of SNAIL transcription factor is elevated in the alveolar subtype of RMS (ARMS), characterized by a low myogenic differentiation status and high aggressiveness. In RMS patients SNAIL level increases with higher stage. Moreover, SNAIL level negatively correlates with MYF5...

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Identifiers

PMID: 29844345
DOI: 10.1038/s41419-018-0693-8
PMCID: PMC5974324

Genes

MYF5
HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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