High frequency of hereditary colorectal cancer in Newfoundland likely involves novel susceptibility genes.

doi:10.1158/1078-0432.CCR-05-0726

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Article

High frequency of hereditary colorectal cancer in Newfoundland likely involves novel susceptibility genes.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2005

Woods Michael O, Hyde Angela J, Curtis Fiona K, Stuckless Susan, Green Jane S, Pollett Aaron F, Robb J Desmond, Green Roger C, Croitoru Marina E, Careen Amanda, Chaulk Jason A W, Jegathesan Jegan, McLaughlin John R, Gallinger Steven S, Younghusband H Banfield, Bapat Bharati V, Parfrey Patrick S

Abstract excerpt

PURPOSE: Newfoundland has one of the highest rates of colorectal cancer in North America. The most common hereditary form of colorectal cancer is hereditary nonpolyposis colorectal cancer caused by mutations in genes involved in mismatch repair. Our purpose was to determine the proportion of hereditary colorectal cancer and to determine the genetic basis of disease in both population and clinically referred...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis

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Identifiers

PMID: 16203774
DOI: 10.1158/1078-0432.CCR-05-0726

Genes

MLH1
MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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