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Article

Genetic and epigenetic regulation of the human prostacyclin synthase promoter in lung cancer cell lines.

Molecular cancer research : MCR - 1 Mar 2007

Stearman Robert S, Grady Michael C, Nana-Sinkam Patrick, Varella-Garcia Marileila, Geraci Mark W

Abstract excerpt

The importance of the arachidonic acid pathway has been established in colon and lung cancers, as well as in inflammatory diseases. In these diseases, prostacyclin I(2) (PGI2) and prostaglandin E(2) (PGE2) are thought to have antagonistic activities, with PGI2 exerting anti-inflammatory and antiproliferative activities, whereas PGE2 is proinflammatory and antiapoptotic. In human lung cancer, prostacyclin synthase...

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PMID: 17374734
DOI: 10.1158/1541-7786.MCR-06-0221

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