Article
Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis.
Clinical science (London, England : 1979) - 1 Apr 2016
Evans Iona C, Barnes Josephine L, Garner Ian M, Pearce David R, Maher Toby M, Shiwen Xu, Renzoni Elisabetta A, Wells Athol U, Denton Christopher P, Laurent Geoffrey J, Abraham David J, McAnulty Robin J
Abstract excerpt
Fibroblasts derived from the lungs of patients with idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc) produce low levels of prostaglandin (PG) E2, due to a limited capacity to up-regulate cyclooxygenase-2 (COX-2). This deficiency contributes functionally to the fibroproliferative state, however the mechanisms responsible are incompletely understood. In the present study, we examined whether the...
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