Article
Clinical significance of aberrant methylation of prostaglandin E receptor 2 (PTGER2) in nonsmall cell lung cancer: association with prognosis, PTGER2 expression, and epidermal growth factor receptor mutation.
Cancer - 15 Sept 2008
Tian Lei, Suzuki Makoto, Nakajima Takahiro, Kubo Rieko, Sekine Yasuo, Shibuya Kiyoshi, Hiroshima Kenzo, Nakatani Yukio, Fujisawa Takehiko, Yoshino Ichiro
Abstract excerpt
BACKGROUND: The expression of prostaglandin E receptor 2 (PTGER2) affects the biologic behavior of various types of malignant tumors. Recently, transactivation of both PTGER2 and epidermal growth factor receptor (EGFR) has been reported in some tumors. METHODS: PTGER2 gene expression and possible aberrant methylation of the PTGER2 gene were investigated in 10 nonsmall cell lung cancer (NSCLC) cell lines, 233...
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