Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension.

American journal of respiratory and critical care medicine - 1 May 2014

Stearman Robert S, Cornelius Amber R, Lu Xiao, Conklin David S, Del Rosario Mark J, Lowe Anita M, Elos Mihret T, Fettig Lynsey M, Wong Randall E, Hara Naoko, Cogan Joy D, Phillips John A, Taylor Matthew R, Graham Brian B, Tuder Rubin M, Loyd James E, Geraci Mark W

Abstract excerpt

RATIONALE: Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated pulmonary artery pressure, vascular remodeling, and ultimately right ventricular heart failure. PAH can have a genetic component (heritable PAH), most often through mutations of bone morphogenetic protein receptor 2, and idiopathic and associated forms. Heritable PAH is not completely penetrant within families,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Protein Receptors, Type II
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to Familial Primary Pulmonary Hypertension

Share to Haplotypes

Share to Heterozygote

Share to Hypertension, Pulmonary

Share to Intramolecular Oxidoreductases

Source

Open in PubMed Open full text

Identifiers

PMID: 24605778
DOI: 10.1164/rccm.201309-1697OC
PMCID: PMC4098107

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension.PMID 24605778Read ↗

Prostacyclin synthase promoter regulation and familial pulmonary arterial hypertension.Semantic proximity Read ↗

BMPR2 Promoter Variants Effect Gene Expression in Pulmonary Arterial Hypertension Patients.Semantic proximity Read ↗

Modulation of the prostaglandin-endoperoxide synthase 2 gene expression by variant haplotypes: influence of the 3'-untranslated region.Semantic proximity Read ↗

Characterization of new mutations in the coding sequence and 5'-untranslated region of the human prostacylcin synthase gene (CYP8A1).Semantic proximity Read ↗

Genetic and epigenetic regulation of the human prostacyclin synthase promoter in lung cancer cell lines.Semantic proximity Read ↗

Novel promoter and exon mutations of the BMPR2 gene in Chinese patients with pulmonary arterial hypertension.Semantic proximity Read ↗

VEGF Promoter Polymorphism Confers an Increased Risk of Pulmonary Arterial Hypertension in a Chinese Population.Semantic proximity Read ↗

Human prostacyclin synthase gene and hypertension : the Suita Study.Semantic proximity Read ↗

Association study between a novel single nucleotide polymorphism of the promoter region of the prostacyclin synthase gene and essential hypertension.Semantic proximity Read ↗

Haplotype analysis of the prostacyclin synthase gene and essential hypertension.Semantic proximity Read ↗

Endothelin-1 Pathway Polymorphisms and Outcomes in Pulmonary Arterial Hypertension.Semantic proximity Read ↗

Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.