Article
Prostacyclin prevents murine lung cancer independent of the membrane receptor by activation of peroxisomal proliferator--activated receptor gamma.
Cancer prevention research (Philadelphia, Pa.) - 1 Oct 2008
Nemenoff Raphael, Meyer Amy M, Hudish Tyler M, Mozer Anthony B, Snee Amy, Narumiya Shuh, Stearman Robert S, Winn Robert A, Weiser-Evans Mary, Geraci Mark W, Keith Robert L
Abstract excerpt
Overexpression of prostacyclin synthase (PGIS) decreases lung tumor multiplicity in chemical- and cigarette-smoke-induced murine lung cancer models. Prostacyclin signals through a single G-protein-coupled receptor (IP), which signals through cyclic AMP. To determine the role of this receptor in lung cancer chemoprevention by prostacyclin, PGIS-overexpressing mice were crossed to mice that lack the IP receptor...
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