Article
Molecular evaluation of pvdhfr and pvmdr-1 mutants in Plasmodium vivax isolates after treatment with sulfadoxine/pyrimethamine and chloroquine in Iran during 2001-2016.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Oct 2018
Parsaei Mahdi, Raeisi Ahmad, Spotin Adel, Shahbazi Abbas, Mahami-Oskouei Mahmoud, Hazratian Teimour, Khorashad Alireza Salimi, Zaman Jalal, Bazmani Ahad, Sarafraz Sedighe
Abstract excerpt
The rising use of sulfadoxine/pyrimethamine (SP) in the treatment of chloroquine (CQ)-resistant Plasmodium falciparum has resulted in increased exposure to P. vivax isolates in Iran, where both species are being circulated. In this investigation, the frequency of pvdhfr and pvmdr-1 mutants was assessed in P. vivax strains during 2001-2016 after the introduction of SP/CQ in malarious areas of Iran. The P. vivax...
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