Article
Similar trends of pyrimethamine resistance-associated mutations in Plasmodium vivax and P. falciparum.
Antimicrobial agents and chemotherapy - 1 Mar 2007
Alam Mohammad Tauqeer, Bora Hema, Bharti Praveen K, Saifi Muheet A, Das Manoj K, Dev Vas, Kumar Ashwani, Singh Neeru, Dash Aditya P, Das Brahmananda, Wajihullah, Sharma Yagya D
Abstract excerpt
The antifolate drugs sulfadoxine and pyrimethamine are commonly used to treat Plasmodium falciparum malaria. However, they can also affect the Plasmodium vivax parasite if it coexists with P. falciparum, as both species have common drug targets. Resistance to the antifolate drugs arises due to point mutations in the target enzymes of the respective parasite. To assess the cross-species impact of antifolate drug...
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