Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis.

Molecular cancer therapeutics - 1 Mar 2007

Wang Jing, Kuropatwinski Karen, Hauser Jennie, Rossi Michael R, Zhou Yunfei, Conway Alexis, Kan Julie L C, Gibson Neil W, Willson James K V, Cowell John K, Brattain Michael G

Abstract excerpt

PIK3CA, encoding the p110alpha catalytic subunit of phosphatidylinositol 3-kinase (PI3K), is mutated in a variety of human cancers. We screened the colon cancer cell lines previously established in our laboratory for PIK3CA mutations and found that four of them harbored gain of function mutations. We have now compared a panel of mutant and wild-type cell lines for cell proliferation and survival in response to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Colonic Neoplasms

Share to Drug Resistance, Neoplasm

Share to Growth Substances

Share to Phosphatidylinositol 3-Kinases

Share to Phosphoinositide-3 Kinase Inhibitors

Source

Identifiers

PMID: 17363507
DOI: 10.1158/1535-7163.MCT-06-0555

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis.PMID 17363507Read ↗

Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model.Semantic proximity Read ↗

Mutant PIK3CA promotes cell growth and invasion of human cancer cells.Semantic proximity Read ↗

Cell line models for drug discovery in PIK3CA-mutated colorectal cancers.Semantic proximity Read ↗

Functional Analysis of PIK3CA Gene Mutations in Human Colorectal CancerSemantic proximity Read ↗

PI3K expression and PIK3CA mutations are related to colorectal cancer metastases.Semantic proximity Read ↗

Dual PI3K/mTOR Inhibition in Colorectal Cancers with APC and PIK3CA MutationsSemantic proximity Read ↗

Aspirin-Induced Chemoprevention and Response Kinetics Are Enhanced by PIK3CA Mutations in Colorectal Cancer Cells.Semantic proximity Read ↗

PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation.Semantic proximity Read ↗

Mutation of the PI3' kinase gene in a human colon carcinoma cell line, HCC2998.Semantic proximity Read ↗

Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K.Semantic proximity Read ↗

p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvationSemantic proximity Read ↗

Blocking phosphoinositide 3-kinase activity in colorectal cancer cells reduces proliferation but does not increase apoptosis alone or in combination with cytotoxic drugs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.