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Article

Mutation of the PI3' kinase gene in a human colon carcinoma cell line, HCC2998.

DNA and cell biology - 1 Jul 2006

Shi Bin-Hi, Nashimoto Takeshi, Andoh Ryota, Konishi Hiroaki, Kobayashi Michimoto, Xu Qingyun, Ihara Sayoko, Fukui Yasuhisa

Abstract excerpt

HCC2998 is a highly differentiated human colon carcinoma cell line, which has been shown to be converted to a poorly differentiated one after expression of a constitutively active phosphatidylinositol 3-kinase (PI3' kinase). These cells express aberrant sizes of a regulatory subunit of PI3' kinase, p85alpha, with molecular weights of 50 and 76 kDa at a very low level. To elucidate how these cells express these...

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PMID: 16848681
DOI: 10.1089/dna.2006.25.399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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