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Aspirin-Induced Chemoprevention and Response Kinetics Are Enhanced by PIK3CA Mutations in Colorectal Cancer Cells.

Cancer prevention research (Philadelphia, Pa.) - 1 Mar 2017

Zumwalt Timothy J, Wodarz Dominik, Komarova Natalia L, Toden Shusuke, Turner Jacob, Cardenas Jacob, Burn John, Chan Andrew T, Boland C Richard, Goel Ajay

Abstract excerpt

This study was designed to determine how aspirin influences the growth kinetics and characteristics of cultured colorectal cancer cells that harbor a variety of different mutational backgrounds, including PIK3CA- and KRAS-activating mutations, and the presence or absence of microsatellite instability. Colorectal cancer cell lines (HCT116, HCT116 + Chr3/5, RKO, SW480, HCT15, CACO2, HT29, and SW48) were treated...

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Aspirin
Class I Phosphatidylinositol 3-Kinases
Colorectal Neoplasms
Cyclooxygenase 2 Inhibitors
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Theoretical

Xenograft Model Antitumor Assays

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Identifiers

PMID: 28154202
DOI: 10.1158/1940-6207.CAPR-16-0175
PMCID: PMC5337164

Genes

KRAS
PCNA

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