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Article

Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model.

Cancer research - 15 Jun 2007

Guo Xiao-Ning, Rajput Ashwani, Rose Rebecca, Hauser Jennie, Beko Alexander, Kuropatwinski Karen, LeVea Charles, Hoffman Robert M, Brattain Michael G, Wang Jing

Abstract excerpt

Mutations in the PIK3CA gene are common in human cancers, including colon cancer. We compared two pairs of colon cancer cells (HCT116 and DLD1) bearing only the wild-type (WT) or mutant (MUT) PIK3CA allele for their survival capacity under stress conditions in vitro as well as their metastatic pr...

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Identifiers

PMID: 17575153
DOI: 10.1158/0008-5472.CAN-07-0049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17575153-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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