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Article

Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration.

Nature communications - 23 Apr 2020

Fragola Giulia, Mabb Angela M, Taylor-Blake Bonnie, Niehaus Jesse K, Chronister William D, Mao Hanqian, Simon Jeremy M, Yuan Hong, Li Zibo, McConnell Michael J, Zylka Mark J

Abstract excerpt

Topoisomerase 1 (TOP1) relieves torsional stress in DNA during transcription and facilitates the expression of long (>100 kb) genes, many of which are important for neuronal functions. To evaluate how loss of Top1 affected neurons in vivo, we conditionally deleted (cKO) Top1 in postmitotic excitatory neurons in the mouse cerebral cortex and hippocampus. Top1 cKO neurons develop properly, but then show biased...

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Identifiers

PMID: 32327659
DOI: 10.1038/s41467-020-15794-9
PMCID: PMC7181881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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