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Article

Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain.

Development (Cambridge, England) - 1 Apr 2007

Andoniadou Cynthia L, Signore Massimo, Sajedi Ezat, Gaston-Massuet Carles, Kelberman Daniel, Burns Alan J, Itasaki Nobue, Dattani Mehul, Martinez-Barbera Juan Pedro

Abstract excerpt

The homeobox gene Hesx1 is an essential repressor that is required within the anterior neural plate for normal forebrain development in mouse and humans. Combining genetic cell labelling and marker analyses, we demonstrate that the absence of Hesx1 leads to a posterior transformation of the anterior forebrain (AFB) during mouse development. Our data suggest that the mechanism underlying this transformation is the...

Topics

Animals
Axin Protein
Cell Differentiation
Cell Line
Cell Lineage
Cytoskeletal Proteins
Eye Proteins
Homeodomain Proteins
Mice
Mice, Knockout

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nerve Tissue Proteins

Prosencephalon

Repressor Proteins

Transcription Factors

Wnt1 Protein

beta Catenin

Homeobox Protein SIX3

Source

Open in PubMed Open full text

Identifiers

PMID: 17360769
DOI: 10.1242/dev.02829
PMCID: PMC2233881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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