Article
Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2.
Development (Cambridge, England) - 1 Dec 2001
Martinez-Barbera J P, Signore M, Boyl P P, Puelles E, Acampora D, Gogoi R, Schubert F, Lumsden A, Simeone A
Abstract excerpt
The anterior neural ridge (ANR), and the isthmic organiser (IsO) represent two signalling centres possessing organising properties necessary for forebrain (ANR) as well as midbrain and rostral hindbrain (IsO) development. An important mediator of ANR and IsO organising property is the signalling molecule FGF8. Previous work has indicated that correct positioning of the IsO and Fgf8 expression in this domain is...
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