Article
Otx2 and HNF3beta genetically interact in anterior patterning.
The International journal of developmental biology - 1 Jan 2001
Jin O, Harpal K, Ang S L, Rossant J
Abstract excerpt
Patterning the developing nervous system in the mouse has been proposed to depend on two separate sources of signals, the anterior visceral endoderm (AVE) and the node or organizer. Mutation of the winged-helix gene HNF3beta leads to loss of the node and its derivatives, while mutation of the homeobox gene Otx2 results in loss of head structures, apparently at least partially because of defects in the AVE. To...
Topics
- Animals
- Body Patterning
- DNA-Binding Proteins
- Endoderm
- Gene Expression Regulation, Developmental
- Hepatocyte Nuclear Factor 3-beta
- Heterozygote
- Homeodomain Proteins
- In Situ Hybridization
- Mesoderm
- Mice