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Article

Effects of the MDM2 promoter SNP285 and SNP309 on Sp1 transcription factor binding and cancer risk.

Transcription - 1 Jan 2000

Knappskog Stian, Lønning Per E

Abstract excerpt

The proto-oncogene MDM2 inhibits p53 and plays a key role in cell growth control and apoptosis. Identification of two antagonizing MDM2 polymorphisms, SNP285 and SNP309, affecting cancer risk through modulation of Sp1 transcription factor binding, shed new light on the biological activity and phylogeny of this gene.

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Share to Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-mdm2

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Share to Sp1 Transcription Factor

Share to Transcription, Genetic

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 22231115
DOI: 10.4161/trns.2.5.16813
PMCID: PMC3265776

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of the MDM2 promoter SNP285 and SNP309 on Sp1 transcription factor binding and cancer risk.PMID 22231115Read ↗

The MDM2 promoter SNP285C/309G haplotype diminishes Sp1 transcription factor binding and reduces risk for breast and ovarian cancer in Caucasians.Semantic proximity Read ↗

MDM2 promoter SNP285 and SNP309; phylogeny and impact on cancer risk.Semantic proximity Read ↗

Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649).Semantic proximity Read ↗

MDM2 promoter SNP344T>A (rs1196333) status does not affect cancer risk.Semantic proximity Read ↗

Influence of MDM2 SNP309 and SNP285 status on the risk of cancer in the breast, prostate, lung and colon.Semantic proximity Read ↗

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.Semantic proximity Read ↗

MDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer.Semantic proximity Read ↗

SNP285C modulates oestrogen receptor/Sp1 binding to the MDM2 promoter and reduces the risk of endometrial but not prostatic cancer.Semantic proximity Read ↗

MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer.Semantic proximity Read ↗

A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.Semantic proximity Read ↗

MDM2 promoter polymorphism SNP309 contributes to tumor susceptibility: evidence from 21 case-control studies.Semantic proximity Read ↗

Contrasting effects of an Mdm2 functional polymorphism on tumor phenotypes.Semantic proximity Read ↗

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