Article
Mdm2 Snp309 G allele displays high frequency and inverse correlation with somatic P53 mutations in hepatocellular carcinoma.
Mutation research - 3 Feb 2010
Acun Tolga, Terzioğlu-Kara Ece, Konu Ozlen, Ozturk Mehmet, Yakicier Mustafa Cengiz
Abstract excerpt
Loss of function of the p53 protein, which may occur through a range of molecular events, is critical in hepatocellular carcinoma (HCC) evolution. MDM2, an oncogene, acts as a major regulator of the p53 protein. A polymorphism in the MDM2 promoter, SNP309 (T/G), has been shown to alter protein expression and may thus play a role in carcinogenesis. MDM2 SNP309 is also associated with HCC. However, the role of...
Topics
- Alleles
- Carcinoma, Hepatocellular
- Gene Frequency
- Genes, p53
- Humans
- Liver Neoplasms
- Mutation
- Polymorphism, Single Nucleotide
- Proto-Oncogene Proteins c-mdm2
- Tumor Suppressor Protein p53