Article
Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain.
Molecular cell - 7 Jan 2005
Ivanov Dmitri, Stone James R, Maki Jenny L, Collins Tucker, Wagner Gerhard
Abstract excerpt
Retroviral assembly is driven by multiple interactions mediated by the Gag polyprotein, the main structural component of the forming viral shell. Critical determinants of Gag oligomerization are contained within the C-terminal domain (CTD) of the capsid protein, which also harbors a conserved sequence motif, the major homology region (MHR), in the otherwise highly variable Gag. An unexpected clue about the MHR...
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