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Article

Mapping of nucleocapsid residues important for HIV-1 genomic RNA dimerization and packaging.

Virology - 5 Jun 2008

Kafaie Jafar, Song Rujun, Abrahamyan Levon, Mouland Andrew J, Laughrea Michael

Abstract excerpt

Retroviral genomic RNA (gRNA) dimerization appears essential for viral infectivity, and the nucleocapsid protein (NC) of human immunodeficiency virus type 1 (HIV-1) facilitates HIV-1 gRNA dimerization. To identify the relevant and dispensable positions of NC, 34 of its 55 residues were mutated, individually or in small groups, in a panel of 40 HIV-1 mutants prepared by site-directed mutagenesis. It was found that...

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Identifiers

PMID: 18343475
DOI: 10.1016/j.virol.2008.02.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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