Article
Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse.
Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2007
Khoo Christine M, Carrasco Daniel R, Bosenberg Marcus W, Paik Ji-Hye, Depinho Ronald A
Abstract excerpt
The Rb/p16(Ink4a) and p53/p19Arf tumor suppressor pathways have been linked to diverse cancer-relevant processes, including those governing the cellular responses to telomere dysfunction. In this study, we sought to provide direct genetic evidence of a role for the Ink4a/Arf tumor suppressor gene, encoding both p16(Ink4a) and p19(Arf), in modulating the cellular and tissue phenotypes associated with telomere...
Topics
- 3T3 Cells
- Animals
- Cyclin-Dependent Kinase Inhibitor p16
- Genes, Tumor Suppressor
- Genes, p53
- In Situ Hybridization, Fluorescence
- Mice
- Mice, Transgenic
- Neoplasms
- Neoplasms, Glandular and Epithelial