Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse.

Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2007

Khoo Christine M, Carrasco Daniel R, Bosenberg Marcus W, Paik Ji-Hye, Depinho Ronald A

Abstract excerpt

The Rb/p16(Ink4a) and p53/p19Arf tumor suppressor pathways have been linked to diverse cancer-relevant processes, including those governing the cellular responses to telomere dysfunction. In this study, we sought to provide direct genetic evidence of a role for the Ink4a/Arf tumor suppressor gene, encoding both p16(Ink4a) and p19(Arf), in modulating the cellular and tissue phenotypes associated with telomere...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, p53
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Neoplasms

Share to Phenotype

Share to Time Factors

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 17360455
DOI: 10.1073/pnas.0700093104
PMCID: PMC1820686

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse.PMID 17360455Read ↗

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse.Semantic proximity Read ↗

Involvement of the INK4a/Arf gene locus in senescence.Semantic proximity Read ↗

Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer.Semantic proximity Read ↗

Tumor spectrum in ARF-deficient mice.Semantic proximity Read ↗

Utilizing murine inducible telomerase alleles in the studies of tissue degeneration/regeneration and cancer.Semantic proximity Read ↗

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.Semantic proximity Read ↗

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.Semantic proximity Read ↗

The INK4a/ARF locus in murine tumorigenesis.Semantic proximity Read ↗

DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse.Semantic proximity Read ↗

ARF functions as a melanoma tumor suppressor by inducing p53-independent senescenceSemantic proximity Read ↗

<i>Ink4‐Arf</i> locus in cancer and agingSemantic proximity Read ↗

Absence of telomerase and shortened telomeres have minimal effects on skin and pancreatic carcinogenesis elicited by viral oncogenes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.