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Article

Utilizing murine inducible telomerase alleles in the studies of tissue degeneration/regeneration and cancer.

Journal of visualized experiments : JoVE - 13 Apr 2015

Shingu Takashi, Jaskelioff Mariela, Yuan Liang, Ding Zhihu, Protopopov Alexei, Kost-Alimova Maria, Hu Jian

Abstract excerpt

Telomere dysfunction-induced loss of genome integrity and its associated DNA damage signaling and checkpoint responses are well-established drivers that cause tissue degeneration during ageing. Cancer, with incidence rates greatly increasing with age, is characterized by short telomere lengths and high telomerase activity. To study the roles of telomere dysfunction and telomerase reactivation in ageing and...

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Identifiers

PMID: 25938254
DOI: 10.3791/52599
PMCID: PMC4526143

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TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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