Article
Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer.
Carcinogenesis - 1 Apr 2008
Perera Samanthi A, Maser Richard S, Xia Huili, McNamara Kate, Protopopov Alexei, Chen Liang, Hezel Aram F, Kim Carla F, Bronson Roderick T, Castrillon Diego H, Chin Lynda, Bardeesy Nabeel, Depinho Ronald A, Wong Kwok-Kin
Abstract excerpt
Current mouse models of lung cancer recapitulate signature genetic lesions and some phenotypic features of human lung cancer. However, because mice have long telomeres, models to date do not recapitulate the aspects of lung carcinogenesis-telomere attrition and the genomic instability that ensues-believed to serve as key mechanisms driving lung tumor initiation and progression. To explore the contributions of...
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