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Article

DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse.

Molecular and cellular biology - 1 Mar 2007

Maser Richard S, Wong Kwok-Kin, Sahin Erguen, Xia Huili, Naylor Maria, Hedberg H Mason, Artandi Steven E, DePinho Ronald A

Abstract excerpt

Telomeres are key structural elements for the protection and maintenance of linear chromosomes, and they function to prevent recognition of chromosomal ends as DNA double-stranded breaks. Loss of telomere capping function brought about by telomerase deficiency and gradual erosion of telomere ends or by experimental disruption of higher-order telomere structure culminates in the fusion of defective telomeres...

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Identifiers

PMID: 17145779
DOI: 10.1128/MCB.01354-06
PMCID: PMC1820500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse.PMID 17145779Read ↗

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