Article
Avian models to study the transcriptional control of hematopoietic lineage commitment and to identify lineage-specific genes.
Cells, tissues, organs - 1 Jan 2002
Nielsen Julie S, Doyonnas Regis, McNagny Kelly M
Abstract excerpt
E26 is an avian acute leukemia virus with a profound ability to transform multipotent hematopoietic progenitor cells both in vivo and in vitro. Progenitor cells transformed by this virus can be expanded in vitro as undifferentiated clones for up to two months and can also be induced to differentiate into cells of the erythroid, eosinophilic, thrombocytic, and myelomonocytic lineages with reproducible kinetics....
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