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Article

v-myb and v-ets transform chicken erythroid cells and cooperate both in trans and in cis to induce distinct differentiation phenotypes.

Genes & development - 1 Mar 1991

Metz T, Graf T

Abstract excerpt

E26 is an acute avian leukemia virus that encodes the transcriptional activator oncogenes v-myb and v-ets in a single fusion protein. This virus is also unique in that it is able to transform hematopoietic cells of both the myeloid and the erythroid lineage. To determine the contributions of v-my...

Topics

Animals
Bone Marrow Cells
Cell Differentiation
Cell Transformation, Viral
Cells, Cultured
Chickens
Erythroblasts
Gene Expression
Histocytochemistry
Oncogene Proteins v-myb
Oncogenes
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Retroviridae Proteins, Oncogenic

Source

Identifiers

PMID: 2001839
DOI: 10.1101/gad.5.3.369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2001839-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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v-myb and v-ets transform chicken erythroid cells and cooperate both in trans and in cis to induce distinct differentiation phenotypes.PMID 2001839Read ↗

Fusion of the nuclear oncoproteins v-Myb and v-Ets is required for the leukemogenicity of E26 virus.Semantic proximity Read ↗

Avian models to study the transcriptional control of hematopoietic lineage commitment and to identify lineage-specific genes.Semantic proximity Read ↗

Mutations in the DNA-binding and transcriptional activation domains of v-Myb cooperate in transformation.Semantic proximity Read ↗

v-Myb DNA binding is required to block thrombocytic differentiation of Myb-Ets-transformed multipotent haematopoietic progenitors.Semantic proximity Read ↗

A functional Ets DNA-binding domain is required to maintain multipotency of hematopoietic progenitors transformed by Myb-Ets.Semantic proximity Read ↗

Back-mutation of the V-Ets to the C-Ets carboxy-terminal amino acids in the P135gag-myb-ets results in chicken neuroretina cells transformation and loss of basic fibroblast growth factor responsiveness.Semantic proximity Read ↗

Marek's disease virus Meq transforms chicken cells via the v-Jun transcriptional cascade: A converging transforming pathway for avian oncovirusesSemantic proximity Read ↗

Avian myeloblastic cell lines transformed by two nuclear oncoproteins, P135gag-myb-ets and p61/63myc: a model of retinoic acid-induced differentiation not abrogated by v-erbA.Semantic proximity Read ↗

Oncogenic mutations cause dramatic, qualitative changes in the transcriptional activity of c-Myb.Semantic proximity Read ↗

Mechanisms for the transformation of myeloid and erythroid cells by the nuclear oncogene V-myb.Semantic proximity Read ↗

Definition of functional domains in P135gag-myb-ets and p48v-myb proteins required to maintain the response of neuroretina cells to basic fibroblast growth factor.Semantic proximity Read ↗

Mutational analysis of the role of the carboxy-terminal region of the v-erbB protein in erythroid cell transformation.Semantic proximity Read ↗

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