Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of 5' regulatory-region polymorphisms on paraoxonase-gene (PON1) expression.

American journal of human genetics - 1 Jun 2001

Brophy V H, Jampsa R L, Clendenning J B, McKinstry L A, Jarvik G P, Furlong C E

Abstract excerpt

Human HDL-associated paraoxonase (PON1) hydrolyzes a number of toxic organophosphorous compounds and reduces oxidation of LDLs and HDLs. These properties of PON1 account for its ability to protect against pesticide poisonings and atherosclerosis. PON1 also hydrolyzes a number of lactone and cyclic-carbonate drugs. Among individuals in a population, PON1 levels vary widely. We previously identified three...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Aryldialkylphosphatase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carboxylic Ester Hydrolases

Share to Esterases

Share to Gene Expression Regulation, Enzymologic

Share to Hepatocytes

Share to Hydrolysis

Share to Phenylacetates

Source

Open in PubMed Open full text

Identifiers

PMID: 11335891
DOI: 10.1086/320600
PMCID: PMC1226129

Genes

PON1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of 5' regulatory-region polymorphisms on paraoxonase-gene (PON1) expression.PMID 11335891Read ↗

Genetic polymorphisms and activity of PON1 in a Mexican population.Semantic proximity Read ↗

Distribution of paraoxonase-1 gene polymorphisms and enzyme activity in a Peruvian population.Semantic proximity Read ↗

Genetic and environmental determinants of the PON-1 phenotype.Semantic proximity Read ↗

Polymorphisms in the human paraoxonase (PON1) promoterSemantic proximity Read ↗

Effects of intronic and exonic polymorphisms of paraoxonase 1 (PON1) gene on serum PON1 activity in a Korean population.Semantic proximity Read ↗

Effects of PON polymorphisms and haplotypes on molecular phenotype in Mexican-American mothers and children.Semantic proximity Read ↗

Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism.Semantic proximity Read ↗

Indications that paraoxonase-1 contributes to plasma high density lipoprotein levels in familial hypercholesterolemia.Semantic proximity Read ↗

Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity.Semantic proximity Read ↗

Haplotype-phenotype relationships of paraoxonase-1.Semantic proximity Read ↗

Genetic and environmental factors associated with plasma paraoxonase activity in healthy Chinese.Semantic proximity Read ↗

Increased influence of genetic variation on PON1 activity in neonates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.