Paraoxonase 1 (PON1) Q192R genotypes and their interaction with smoking strongly increase atherogenicity and the Framingham risk score.

doi:10.1590/2359-3997000000184

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Article

Paraoxonase 1 (PON1) Q192R genotypes and their interaction with smoking strongly increase atherogenicity and the Framingham risk score.

Archives of endocrinology and metabolism - 1 Oct 2016

Souza-Nogueira Andre de, Camargo Alissana Ester, Remondi Felipe Assan, Paoliello Monica Maria Bastos, Richter Rebecca J, Furlong Clement E, Barbosa Decio Sabbatini, Maes Michael, Moreira Estefania Gastaldello

Abstract excerpt

OBJECTIVE: Paraoxonase 1 (PON1) polymorphisms are associated with an increased susceptibility to cardiovascular disease. PON1 Q192R polymorphism (rs662) partially determine PON1 hydrolytic activity and protect against oxidation of LDL and HDL. This study aimed to delineate the association of PON1 status (functional 192 genotype and plasma activity levels) and atherogenicity in urbans residents aged 40 years or...

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Identifiers

PMID: 27812605
DOI: 10.1590/2359-3997000000184
PMCID: PMC10118632

Genes

PON1
AIP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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