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Article

Distinct faces of the Ku heterodimer mediate DNA repair and telomeric functions.

Nature structural & molecular biology - 1 Apr 2007

Ribes-Zamora Albert, Mihalek Ivana, Lichtarge Olivier, Bertuch Alison A

Abstract excerpt

The Ku heterodimer, comprised of Ku70 and Ku80 subunits, is a conserved complex involved in nonhomologous end-joining (NHEJ). However, it also functions in maintenance of telomeres, chromosome termini normally resistant to end-joining events. To elucidate the spatial organization of these functions, we rationally guided Ku mutagenesis in yeast with real-valued evolutionary trace (rvET). This revealed two...

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Share to Antigens, Nuclear
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Source

Identifiers

PMID: 17351632
DOI: 10.1038/nsmb1214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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