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Article

Dual role for SUMO E2 conjugase Ubc9 in modulating the transforming and growth-promoting properties of the HMGA1b architectural transcription factor.

The Journal of biological chemistry - 4 May 2007

Li Youjun, Lu Jie, Prochownik Edward V

Abstract excerpt

Members of the HMGA1 (high mobility group A1) family of architectural transcription factors, HMGA1a and HMGA1b, play important roles in many normal cellular processes and in tumorigenesis. We performed a yeast two-hybrid screen for HMGA1-interacting proteins and identified the SUMO E2 conjugase Ubc9 as one such partner. The Ubc9-interacting domain of HMGA1 is bipartite, consisting of a proline-rich region near...

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Share to Cell Proliferation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Processing, Post-Translational

Share to Protein Structure, Tertiary

Share to SUMO-1 Protein

Share to Two-Hybrid System Techniques

Share to Ubiquitin-Conjugating Enzyme UBC9

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Source

Identifiers

PMID: 17350957
DOI: 10.1074/jbc.M610919200

Genes

HMGA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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