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Article

Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection.

Nature structural & molecular biology - 1 Jan 2005

Tatham Michael H, Kim Suhkmann, Jaffray Ellis, Song Jing, Chen Yuan, Hay Ronald T

Abstract excerpt

The conjugation of small ubiquitin-like modifiers SUMO-1, SUMO-2 and SUMO-3 onto target proteins requires the concerted action of the specific E1-activating enzyme SAE1/SAE2, the E2-conjugating enzyme Ubc9, and an E3-like SUMO ligase. NMR chemical shift perturbation was used to identify the surface of Ubc9 that interacts with the SUMO ligase RanBP2. Unlike known ubiquitin E2-E3 interactions, RanBP2 binds to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15608651
DOI: 10.1038/nsmb878

Genes

PML
SAE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection.PMID 15608651Read ↗

Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation.Semantic proximity Read ↗

Structure and analysis of a complex between SUMO and Ubc9 illustrates features of a conserved E2-Ubl interaction.Semantic proximity Read ↗

DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes.Semantic proximity Read ↗

The RanBP2/RanGAP1∗SUMO1/Ubc9 Complex Is a Multisubunit SUMO E3 LigaseSemantic proximity Read ↗

Modification of Ran GTPase-activating protein by the small ubiquitin-related modifier SUMO-1 requires Ubc9, an E2-type ubiquitin-conjugating enzyme homologue.Semantic proximity Read ↗

Identification of a substrate recognition site on Ubc9.Semantic proximity Read ↗

Sumoylation of the nucleocapsid protein of severe acute respiratory syndrome coronavirus by interaction with Ubc9.Semantic proximity Read ↗

SUMOylation and deSUMOylation at a glanceSemantic proximity Read ↗

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A stable chemical SUMO1-Ubc9 conjugate specifically binds as a thioester mimic to the RanBP2-E3 ligase complex.Semantic proximity Read ↗

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