Article
The HMGA1 protoncogene frequently deregulated in cancer is a transcriptional target of E2F1.
Molecular carcinogenesis - 1 Jul 2013
Massimi Isabella, Guerrieri Francesca, Petroni Marialaura, Veschi Veronica, Truffa Silvia, Screpanti Isabella, Frati Luigi, Levrero Massimo, Gulino Alberto, Giannini Giuseppe
Abstract excerpt
Reactivation of the HMGA1 protoncogene is very frequent in human cancer, but still very little is known on the molecular mechanisms leading to this event. Prompted by the finding of putative E2F binding sites in the human HMGA1 promoter and by the frequent deregulation of the RB/E2F1 pathway in human carcinogenesis, we investigated whether E2F1 might contribute to the regulation of HMGA1 gene expression. Here we...
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