Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery

31 Jul 2007

Abstract excerpt

Actin polymerization is crucial in throm-bopoiesis, platelet adhesion, and mega-karyocyte (MK) and platelet spreading. The Wiskott-Aldrich syndrome protein (WASp) homolog WAVE functions downstream of Rac and plays a pivotal role in lamellipodia formation. While MKs and platelets principally express WAVE1 and WAVE2, which are associated with Abi1, the physiologic significance of WAVE isoforms remains undefined. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation and Thrombosis Mechanisms
Share to Platelet Disorders and Treatments
Share to Renal Diseases and Glomerulopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17664349
DOI: 10.1182/blood-2007-04-085860

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machineryPMID 17664349Read ↗

WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility.Semantic proximity Read ↗

The Role of WAVE2 Signaling in CancerSemantic proximity Read ↗

Restrained activation of CYFIP2-containing WAVE complexes controls membrane protrusions and cell migrationSemantic proximity Read ↗

The WASP and WAVE family proteinsSemantic proximity Read ↗

Novel insights into mouse models of ectopic proplatelet releaseSemantic proximity Read ↗

The genomic and proteomic blueprint of mouse megakaryocytes derived from embryonic stem cells.Semantic proximity Read ↗

WASP and WAVE family proteins: Friends or foes in cancer invasion?Semantic proximity Read ↗

Insights into Regulatory Factors in Megakaryocyte Development and Function: Basic Mechanisms and Potential TargetsSemantic proximity Read ↗

Megakaryocyte Cytoskeletal Proteins in Platelet Biogenesis and DiseasesSemantic proximity Read ↗

Regulation of WAVE1 expression in macrophages at multiple levels.Semantic proximity Read ↗

Loss of Hem1 disrupts macrophage function and impacts on migration, phagocytosis and integrin-mediated adhesionSemantic proximity Read ↗

Common features of megakaryocytes and hematopoietic stem cells: What's the connection?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.