Article
Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins.
Blood - 7 May 2009
O'Connor Marie N, Salles Isabelle I, Cvejic Ana, Watkins Nicholas A, Walker Adam, Garner Stephen F, Jones Chris I, Macaulay Iain C, Steward Michael, Zwaginga Jaap-Jan, Bray Sarah L, Dudbridge Frank, de Bono Bernard, Goodall Alison H, Deckmyn Hans, Stemple Derek L, Ouwehand Willem H
Abstract excerpt
In this study, we demonstrate the suitability of the vertebrate Danio rerio (zebrafish) for functional screening of novel platelet genes in vivo by reverse genetics. Comparative transcript analysis of platelets and their precursor cell, the megakaryocyte, together with nucleated blood cell elements, endothelial cells, and erythroblasts, identified novel platelet membrane proteins with hitherto unknown roles in...
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