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Article

Discovery properties of genome-wide association signals from cumulatively combined data sets.

American journal of epidemiology - 15 Nov 2009

Pereira Tiago V, Patsopoulos Nikolaos A, Salanti Georgia, Ioannidis John P A

Abstract excerpt

Genetic effects for common variants affecting complex disease risk are subtle. Single genome-wide association (GWA) studies are typically underpowered to detect these effects, and combination of several GWA data sets is needed to enhance discovery. The authors investigated the properties of the discovery process in simulated cumulative meta-analyses of GWA study-derived signals allowing for potential genetic...

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Identifiers

PMID: 19808636
DOI: 10.1093/aje/kwp262
PMCID: PMC2800267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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