Article
Single tube genotyping of GSTM1, GSTT1 and TP53 polymorphisms by multiplex PCR.
DNA sequence : the journal of DNA sequencing and mapping - 1 Oct 2006
Bottari Fabio, Landi Stefano, Gemignani Federica
Abstract excerpt
Glutathione S-transferases (GST) are enzymes involved in the conjugation of a number of human carcinogens, while p53 tumour suppressor gene is the most frequently mutated gene identified till now in human neoplasias. Typically, GSTM1 and GSTT1 genotyping are performed together, with several different protocol described and sometimes with the risk of misclassification due to "false negative", depending on the...
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