Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of p53 genomic instability with the glutathione S-transferase null genotype in gastric cancer in the Portuguese population.

Molecular pathology : MP - 1 Jun 1999

Conde A R, Martins G, Saraiva C, Rueff J, Monteiro C

Abstract excerpt

AIMS: p53 gene mutations are the most common genetic changes known to occur in human cancer. In previous studies, the presence of alterations to the p53 gene has been linked to the null phenotype of the glutathione S-transferase mu gene (GSTM1). GSTM1 appears to be part of a protective mechanism against the development of cancers in which environmental chemical carcinogens are involved. To screen for such an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Genes, p53
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione Transferase

Share to Loss of Heterozygosity

Share to Microsatellite Repeats

Share to Polymerase Chain Reaction

Share to Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 10621833
DOI: 10.1136/mp.52.3.131
PMCID: PMC395686

Genes

GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of p53 genomic instability with the glutathione S-transferase null genotype in gastric cancer in the Portuguese population.PMID 10621833Read ↗

Relevance of GSTM1, GSTT1, and GSTP1 gene polymorphisms to gastric cancer susceptibility and phenotype.Semantic proximity Read ↗

Glutathione S-transferase M1 status and gastric cancer risk: a meta-analysis.Semantic proximity Read ↗

Glutathione S-transferase T1 and M1 genotypes in normal mucosa, transitional mucosa and colorectal adenocarcinoma.Semantic proximity Read ↗

Glutathione S-transferase gene polymorphisms in celiac disease and their correlation with genomic instability phenotype.Semantic proximity Read ↗

Glutathione S-transferase genotype and p53 mutations in adenocarcinoma of the small intestine.Semantic proximity Read ↗

Single tube genotyping of GSTM1, GSTT1 and TP53 polymorphisms by multiplex PCR.Semantic proximity Read ↗

Diet, Helicobacter pylori, and p53 mutations in gastric cancer: a molecular epidemiology study in Italy.Semantic proximity Read ↗

[Effect of gene polymorphism on detoxifying glutathione-S-transferase enzymes on chromosomal stability of squamous epithelial carcinomas in the area of the head-neck].Semantic proximity Read ↗

Genetic polymorphisms of carcinogen metabolizing enzymes are associated with oral leukoplakia development and p53 overexpression.Semantic proximity Read ↗

Helicobacter pylori and the null genotype of glutathione-S-transferase-mu in patients with gastric adenocarcinoma.Semantic proximity Read ↗

Chromosomal instability rather than p53 mutation is associated with response to neoadjuvant cisplatin-based chemotherapy in gastric carcinoma.Semantic proximity Read ↗

Polymorphism of GSTM1 gene in patients with colorectal cancer and colonic polyps.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.