Article
Single tube multiplex polymerase chain reaction genotype analysis of GSTM1, GSTT1 and GSTP1: relation of genotypes to TP53 tumor status and clinicopathological variables in breast cancer patients.
Pharmacogenetics - 1 Oct 1998
Nedelcheva Kristensen V, Andersen T I, Erikstein B, Geitvik G, Skovlund E, Nesland J M, Børresen-Dale A L
Abstract excerpt
Glutathione S-transferases are involved in the conjugation of a number of human carcinogens. The frequencies of the deletion alleles coding for GSTM1, and GSTT1, related to deficient conjugation of xenobiotics, as well as a recently reported variant in the exon 5 of GSTP1 were investigated in thi...
Topics
- Adult
- Aged
- Breast Neoplasms
- Female
- Gene Frequency
- Genes, p53
- Genotype
- Glutathione Transferase
- Humans
- Loss of Heterozygosity
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Sequence Deletion