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Article

Genetic risk score informed re-evaluation of phenotype quality control to maximise power in epidemiological studies: application to lung function.

International journal of population data science - 1 Jan 2026

Chen Jing, Shrine Nick, Izquierdo Abril G, Guyatt Anna, Williams Alex, Völzke Henry, London Stephanie, Hall Ian P, Dudbridge Frank, Wain Louise V, Tobin Martin D, John Catherine

Abstract excerpt

Introduction: Clinical guidelines may reduce statistical power in epidemiological studies by discarding informative measures. Epidemiological studies of lung function may discard one-third to one-half of participants due to spirometry measures deemed "low quality" using criteria adapted from clinical practice. Objectives: To optimise the signal-to-noise ratio in epidemiological studies of lung function, we aimed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41684607
DOI: 10.23889/ijpds.v11i1.2997
PMCID: PMC12893191

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