Article
The informative error: A framework for the construction of individualized phenotypes.
Statistical methods in medical research - 1 May 2019
Hertel Johannes, Frenzel Stefan, König Johanna, Wittfeld Katharina, Fuellen Georg, Holtfreter Birte, Pietzner Maik, Friedrich Nele, Nauck Matthias, Völzke Henry, Kocher Thomas, Grabe Hans J
Abstract excerpt
For the goal of individualized medicine, it is critical to have clinical phenotypes at hand which represent the individual pathophysiology. However, for most of the utilized phenotypes, two individuals with the same phenotype assignment may differ strongly in their underlying biological traits. In this paper, we propose a definition for individualization and a corresponding statistical operationalization,...
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