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Article

Power loss for linkage analysis due to the dichotomization of trichotomous phenotypes.

Human heredity - 1 Jan 2004

Corbett Jonathan, Gu C Charles, Rice John P, Reich Theodore, Province Michael A, Rao D C

Abstract excerpt

OBJECTIVES: Some traits, while naturally polychotomous, are routinely dichotomized for genetic analysis. Dichotomization, intuitively, leads to a loss of power to detect linkage, as some phenotypic variability is discarded. This paper examines this power loss in the context of a trichotomous trait. METHODS: To examine this power loss, we performed a simulation study where a trichotomous trait was simulated in a...

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PMID: 15133309
DOI: 10.1159/000077386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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