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Article

CYP2C19 expression modulates affective functioning and hippocampal subiculum volume-a large single-center community-dwelling cohort study.

Translational psychiatry - 5 Aug 2022

Grosu Claire, Trofimova Olga, Gholam-Rezaee Mehdi, Strippoli Marie-Pierre F, Kherif Ferath, Lutti Antoine, Preisig Martin, Draganski Bogdan, Eap Chin B

Abstract excerpt

Given controversial findings of reduced depressive symptom severity and increased hippocampus volume in CYP2C19 poor metabolizers, we sought to provide empirical evidence from a large-scale single-center longitudinal cohort in the community-dwelling adult population-Colaus|PsyCoLaus in Lausanne, Switzerland (n = 4152). We looked for CYP2C19 genotype-related behavioral and brain anatomy patterns using a...

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PMID: 35931695
DOI: 10.1038/s41398-022-02091-w
PMCID: PMC9356029

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