Article
Effect of the angiotensinogen genotype on experimental hypertension in mice.
Journal of molecular medicine (Berlin, Germany) - 1 Apr 2007
Handtrack Claudia, Cordasic Nada, Klanke Bernd, Veelken Roland, Hilgers Karl F
Abstract excerpt
Polymorphisms of the angiotensinogen (Agt) gene may affect blood pressure. We used a mouse model to test for the role of the Agt genotype in low-renin or high-renin forms of hypertension. Mice bearing one, two, three, or four copies of the Agt gene underwent renal artery clipping to induce high-r...
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